(1,2,6,7,-Tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile synthesis

Yield:221530-44-5 93%

Reaction Conditions:

with piperidine at 100 - 110;

Steps:

1

Example 1; Synthesis of (1, 6,7,8-Tetrahydro-2H-indeno-[5,4-b]furan-8-ylidene) -acetonitrile; l,2,6,7-Tetrahydro-8H-indeno-[5,4-b]furan-8-one (100 gm, 0.5747 mol ) and cyano acetic acid ( 75 gm, 0.8823 mol ) were added in piperidine (400 ml ) at ambient temperature. The reaction mass was heated to 100-110°C and then cooled to 55°C and the piperidine was removed under reduced pressure below 55°C. Water (500 ml) was added to the residue and extracted with dichloromethane (3 X 500 ml). Organic layer was washed with brine and distilled under reduced pressure below 50°C. The solid was stirred in heptane (500 ml), filtered, washed with heptane and dried under vacuum at 50-60°C to give 106 gms of the title compound.Yield:- 93%

References:

WO2012/35303,2012,A2 Location in patent:Page/Page column 23