5-(Chloroformyl)-2,4-difluoronitrobenzene, 5-(Chlorocarbonyl)-2,4-difluoronitrobenzene synthesis
- Product Name:5-(Chloroformyl)-2,4-difluoronitrobenzene, 5-(Chlorocarbonyl)-2,4-difluoronitrobenzene
- CAS Number:221560-09-4
- Molecular formula:C7H2ClF2NO3
- Molecular Weight:221.55
79-37-8
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Yield:221560-09-4 95.2%
Reaction Conditions:
in dichloromethane;N,N-dimethyl-formamide;
Steps:
45 Preparation of 2,4-Difluoro-5-nitrobenzoyl Chloride STR186
EXAMPLE 45 Preparation of 2,4-Difluoro-5-nitrobenzoyl Chloride STR186 Oxalyl chloride (94.0 g, 0.739 mol) is added dropwise to a mixture of 2,4-difluoro-5-nitrobenzoic acid (100.0 g, 0.492 mol), methylene chloride and N,N-dimethylformamide (0.600 ml). The resultant mixture is stirred 3.25 hours at reflux, cooled to room temperature, and concentrated in vacuo to afford the title compound as a brown oil (111 g, 95.2%).
References:
US6140270,2000,A
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1583-58-0
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