ChemicalBook CAS DataBase List 1-(4-FLUOROPHENYL)-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE

1-(4-FLUOROPHENYL)-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE synthesis

5synthesis methods

Product Name:1-(4-FLUOROPHENYL)-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE
CAS Number:221620-96-8
Molecular formula:C17H15FN2
Molecular Weight:266.31

61-54-1 Synthesis

61-54-1
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$12.00/5G

459-57-4 Synthesis

459-57-4
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$6.00/25g

1-(4-FLUOROPHENYL)-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE

221620-96-8
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$150.00/250mg

Yield:221620-96-8 92%

Reaction Conditions:

with 4-nitro-benzoic acid at 140; for 24 h;Inert atmosphere;

Steps:

1-(4-Nitrophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole[30] (4a)

General procedure: In an 5 ml RB flask with refluxing condensor were added a mixtureof 4-nitrobenzaldehyde (2a, 33 mg, 0.22 mmol, 1.1 equiv.,), tryptamine(1a, 32 mg, 0.20 mmol, 1 equiv.,) and 4-nitrobenzoic acid (6.7 mg, 0.1equiv.,) in NMP (1 ml) under argon atmosphere and the resultingmixture was stirred at 140 °C for 24 h. After the reaction was complete,the reaction mixture was concentrated under reduced pressure usingrotary evaporator. The crude product thus obtained was purified byflash column chromatography on silica gel using mixture of hexane -ethyl acetate (70:30) as eluent to obtain the product 4a Yellow solid:89% yield (52 mg, 0.178 mmol); mp: 170-172 °C (Lit6f: 172-173 °C);

References:

Ramu;Srinath;kumar, A. Aswin;Baskar;Ilango;Balasubramanian [Molecular catalysis,2019,vol. 468,p. 86 - 93]

61-54-1 Synthesis

61-54-1
496 suppliers
$12.00/5G

459-56-3 Synthesis