ChemicalBook CAS DataBase List BenzaMide, N-(4-Methyl-3-nitrophenyl)-3-(trifluoroMethyl)-

BenzaMide, N-(4-Methyl-3-nitrophenyl)-3-(trifluoroMethyl)- synthesis

5synthesis methods

Product Name:BenzaMide, N-(4-Methyl-3-nitrophenyl)-3-(trifluoroMethyl)-
CAS Number:221876-21-7
Molecular formula:C15H11F3N2O3
Molecular Weight:324.25

2251-65-2 Synthesis

2251-65-2
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$10.00/1g

119-32-4 Synthesis

119-32-4
255 suppliers
$15.00/25g

BenzaMide, N-(4-Methyl-3-nitrophenyl)-3-(trifluoroMethyl)-

221876-21-7
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Yield:221876-21-7 100%

Reaction Conditions:

Stage #1: 3-(Trifluoromethyl)benzoyl chloride;4-Methyl-3-nitroanilinwith triethylamine in dichloromethane at 25; for 0.333333 h;
Stage #2: with water in dichloromethane; for 0.25 h;

Steps:

111

A solution of 4-methyl-3-nitro-phenylamine (3.64 g, 24 mmol) and 3-trifluoromethyl benzoyl chloride (5 g, 24 mmol) in DCM (100 ml) was treated with triethylamine (4.85 g, 48 mmol). The mixture was stirred at 25 °C for 20 min. The reaction was then quenched with water (50 ml) and stirred for 15 min. The solid was collected by vacuum filtration and washed with hexane. A second crop of solid was collected from the filtrate to give a total yield of 7.78 g (100%) of white-light yellow solid. NMR: 7.35 (m, 1Η), 7.66 (m, 1Η), 7.87 (m, 2Η), 8.15 (m, 2H), 8.40 (s, IH), 10.62 (s, IH); m/z 324.

References:

WO2006/24834,2006,A1 Location in patent:Page/Page column 72

454-92-2 Synthesis