5,7-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester synthesis
- Product Name:5,7-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester
- CAS Number:228728-82-3
- Molecular formula:C12H9F2NO3
- Molecular Weight:253.2
Yield:228728-82-3 62%
Reaction Conditions:
Stage #1: 3,5-difluoroaniline;diethyl 2-ethoxymethylenemalonate in neat (no solvent) at 120; for 1 h;Inert atmosphere;
Stage #2: with Eaton′s Reagent in neat (no solvent) at 130; for 1 h;Inert atmosphere;
References:
Kingsbury, Alex;Brough, Steve;McCarthy, Antonio Pedrina;Lewis, William;Woodward, Simon [European Journal of Inorganic Chemistry,2020,vol. 2020,# 11-12,p. 1011 - 1017] Location in patent:supporting information
![DIETHYL 2-[(3,5-DIFLUOROANILINO)METHYLENE]MALONATE](/StructureFile/ChemBookStructure2/GIF/CB1268357.gif)
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