2-Propen-1-one, 1-(4-fluorophenyl)-3-phenyl-, (2E)- synthesis
- Product Name:2-Propen-1-one, 1-(4-fluorophenyl)-3-phenyl-, (2E)-
- CAS Number:22966-25-2
- Molecular formula:C15H11FO
- Molecular Weight:226.25
Yield:22966-25-2 94%
Reaction Conditions:
with sodium hydroxide in ethanol at 15 - 25;
Steps:
1 (1) Preparation of 4-fluorochalcone la
(1) In a 100 mL round-bottomed flask, 15 mL of ethanol was added, 25 mL of 10% sodium hydroxide solution and 5 mL (0.05 mol) of benzaldehyde, Under stirring at room temperature, 6 mL (0.05 mol) of fluoroacetophenone was slowly added dropwise, Upon completion of the addition, 15-25 ° C stirring 2-3 hours, Until there is light yellow floc generated, Stirring was continued for half an hour and allowed to stand for half an hour under an ice bath to allow more solids to precipitate. The resulting solid was filtered and recrystallized from ethanol to give intermediate la. 1b-ld synthesis and la similar. The yield was 89% ~ 94%
References:
CN106083763,2016,A Location in patent:Paragraph 0010
