ChemicalBook CAS DataBase List tert-Butyl 4-(4-(ethoxycarbonyl)phenyl)piperazine-1-carboxylate

tert-Butyl 4-(4-(ethoxycarbonyl)phenyl)piperazine-1-carboxylate synthesis

7synthesis methods

Product Name:tert-Butyl 4-(4-(ethoxycarbonyl)phenyl)piperazine-1-carboxylate
CAS Number:234082-33-8
Molecular formula:C18H26N2O4
Molecular Weight:334.41

5798-75-4 Synthesis

5798-75-4
191 suppliers
$6.00/5g

57260-71-6 Synthesis

57260-71-6
740 suppliers
$5.00/5g

tert-Butyl 4-(4-(ethoxycarbonyl)phenyl)piperazine-1-carboxylate

234082-33-8
40 suppliers
$55.00/250mg

Yield:234082-33-8 87%

Reaction Conditions:

with tris-(dibenzylideneacetone)dipalladium⁽⁰⁾;caesium carbonate;ruphos in toluene at 95;Inert atmosphere;

Steps:

8.1

Step 1: A mixture of compound 1 (45.6 g, 0.2 mol), Boc-piperazine (112 g, 0.6 mol), Pd2(dba)3 (18.3 g, 0.02 mol), RuPhos (9 g, 0.02 mol), Cs2C03 (195 g, 0.6 mol) in tolune (400 mL) was stirred at 95 °C under N₂overnight. The mixture was added to EA (200 mL), filtered and concentrated to get a residue, which was washed by PE to afford compound 2 (57 g, 87%) as a light yellow solid.

References:

WO2016/57779,2016,A2 Location in patent:Page/Page column 70; 71

451-46-7 Synthesis