tert-butyl 4-(2-aMinoethyl)-3-oxopiperazine-1-carboxylate synthesis

4synthesis methods

Product Name:tert-butyl 4-(2-aMinoethyl)-3-oxopiperazine-1-carboxylate
CAS Number:234108-58-8
Molecular formula:C11H21N3O3
Molecular Weight:243.3

tert-butyl 4-(cyanomethyl)-3-oxopiperazine-1-carboxylate

234108-59-9
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tert-butyl 4-(2-aMinoethyl)-3-oxopiperazine-1-carboxylate

234108-58-8
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$47.00/100mg

Yield:234108-58-8 93%

Reaction Conditions:

with platinum(IV) oxide;palladium on activated charcoal;hydrogen in ethanol at 20; under 2585.81 Torr;

Steps:

20.2 tert-Butyl 4-(2-aminoethyl)-3-oxopiperazine-1-carboxylate

step 2: A mixture of tert-butyl 4-(cyanomethyl)-3-oxopiperazine-1-carboxylate (3.0 g, 12.5 mmol), PtO₂(300 mg, 1.32 mmol) in EtOH (20 mL) was stirred at 20° C. under H₂(50 psi) overnight. The Pd/C catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to afford tert-butyl 4-(2-aminoethyl)-3-oxopiperazine-1-carboxylate (2.8 g, 93%) as yellow solid. LCMS (ESI): m/z=244.2 [M+1]⁺.

References:

US2015/31674,2015,A1 Location in patent:Paragraph 0303; 0305; 0729

76003-29-7 Synthesis

76003-29-7
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234108-58-8
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References

1-Piperazinecarboxylic acid, 4-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3-oxo-, 1,1-dimethylethyl ester

786683-69-0
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234108-58-8
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References

910573-06-7 Synthesis

tert-butyl 4-(2-hydroxyethyl)-3-oxopiperazine-1-carboxylate

910573-06-7
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$307.00/100mg

234108-58-8
35 suppliers
$47.00/100mg

References