2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis
- Product Name:2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS Number:236406-39-6
- Molecular formula:C13H24N2O2
- Molecular Weight:240.34
142851-03-4
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236406-39-6
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Yield:-
Steps:
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 20 °C
2.1: osmium(VIII) oxide / water; tetrahydrofuran / 0.08 h
2.2: 3 h / 20 °C
3.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - 20 °C
5.1: ammonium formate; palladium 10% on activated carbon / methanol / 1 h / Reflux
References:
SHIRE INTERNATIONAL GMBH;CREMONESI, Susanna;LUKER, Tim;SEMERARO, Teresa;MICHELI, Fabrizio WO2016/42452, 2016, A1
236406-38-5
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236406-39-6
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146603-99-8
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236406-39-6
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1228603-43-7
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236406-39-6
182 suppliers
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1221818-05-8
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236406-39-6
182 suppliers
$60.00/100mg