N-(2-Ethoxyphenyl)-N'-(4-ethylphenyl)-ethlyene diamide synthesis

Yield:23949-66-8 90%

Reaction Conditions:

with sodium methylate at 130; for 8 h;Reagent/catalyst;Temperature;

Steps:

1.3; 2.3; 3.3 (3) Synthesis of N- (2-ethoxyphenyl) -N '-(4-ethylphenyl) glyoxamide product:

Using anthranilyl ether and the oxalimide intermediate obtained in step (2) as raw materials, The molar ratio of the oxamide intermediate and the anthranilyl ether is 1: 2. Adding sodium methoxide as a catalyst to the reaction system, Heat and stir, and react at 130 ° C for 8 hours. Then at 120 ° C, Evaporate the ethanol by-products, lower the temperature to 90 ° C, pour into 50 ° C methanol and stir to dissolve. The insoluble matter is filtered off, the mother liquor is crystallized by cooling, and filtered, Dry to obtain N- (2-ethoxyphenyl) -N '-(4-ethylphenyl) glyoxamide product. N- (2-ethoxyphenyl) -N '-(4-ethylphenyl) glyoxamide has a purity of 98.8%, The yield is 90%. The quantitative detection by liquid chromatography is shown in Figure 1. Infrared chromatographic detection is shown in Figure 2, and DSC detection is shown in Figure 3.

References:

CN110343053,2019,A Location in patent:Page/Page column 5-7