13-Isopropylpodocarpa-8,11,13-trien-19-oic acid methyl ester synthesis

Yield:-

Steps:

Multi-step reaction with 6 steps
1: N-Bromosuccinimide / acetonitrile / 0.5 h / 90 °C / Microwave irradiation
2: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / 1,3-dioxane; water / 0.5 h / 135 °C / Microwave irradiation
3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 20 h / 20 °C
4: toluene; methanol; hexane / 1 h / 20 °C
5: pyridine / dichloromethane / 1 h / 0 °C
6: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; N-ethyl-N,N-diisopropylamine; formic acid / N,N-dimethyl-formamide / 0.5 h / 110 °C / Microwave irradiation

References:

Wu, Xiongyu;Silver? Ejneby, Malin;Ottosson, Nina E;Elinder, Fredrik;Konradsson, Peter [European Journal of Organic Chemistry,2018,vol. 2018,# 14,p. 1730 - 1734]