(4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid Methyl ester synthesis

Yield:24127-59-1 82%

Reaction Conditions:

with triethylamine in tetrahydrofuran at 0 - 60; for 1 h;

Steps:

1.1 Step 1. Synthesis of Compound IV-1

Add compound II-1 (8 g, 0.08 mol) to tetrahydrofuran (500 ml) with stirring at room temperature.Methyl bromoacetate (III-1, 16 g, 0.10 mol) was added and the temperature of the system was lowered to 0 °C.At this time, triethylamine (20 ml) was added dropwise to the system, and the system was heated to 60 ° C and stirred for 1 h.It was then cooled to room temperature and stirring was continued for 12 h at which time TLC showed the reaction was completed.The reaction mixture was filtered, and the solvent was evaporated.Filtration, collection of the filter cake, blast drying at 40 ° C to give compound IV-1, white solid, 11.3 g,The yield was 82%.

References:

CN108658879,2018,A Location in patent:Paragraph 0039; 0041; 0043; 0044