4-(1H-Pyrazolo[3,4-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester synthesis

4synthesis methods

Product Name:4-(1H-Pyrazolo[3,4-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
CAS Number:245450-02-6
Molecular formula:C14H20N6O2
Molecular Weight:304.35

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57260-71-6 Synthesis

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4-(1H-Pyrazolo[3,4-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

245450-02-6
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Yield:245450-02-6 89%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide at 90; for 4 h;

Steps:

1 Preparation of Intermediate 2

The starting material B-Cl(1a-n) (12.94 mmol) was weighed and dissolved in DMF (10 mL).DIEA (51.76mmol),1-Boc piperazine (15.53 mmol) was added to the reaction flask and reacted at 90 ° C for 4 h.The reaction was completely detected by TLC, and the reaction solution was poured into 10 times of ice water.A large amount of white solid was precipitated, filtered, and the cake was washed with water (20 ml × 3) and dried.Intermediate 2 was obtained. In the above preparation, la is 4-chloro-1H-pyrazolo[3,4-d]pyrimidine, which gives 2a as a white solid, yield 89%

References:

CN108822110,2018,A Location in patent:Paragraph 0112-0116