(2E)-3-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester synthesis
- Product Name:(2E)-3-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester
- CAS Number:245467-31-6
- Molecular formula:C14H19NO3
- Molecular Weight:249.31
Yield:245467-31-6 93.6%
Reaction Conditions:
with potassium carbonate;potassium iodide in N,N-dimethyl-formamide at 80; for 10 h;Reagent/catalyst;Temperature;Solvent;
Steps:
1-7 Example 4
Methyl p-hydroxycinnamic acid (4.12 g, 23.1 mmol), N, N-dimethylaminochloroethane hydrochloride (34.65 mmol), N, N-dimethylformamide 41.2 ml, potassium carbonate (184.8 mmol ), Potassium iodide (11.55 mmol) was added to the reaction flask, heated to 80 ° C. with stirring, and the reaction was held for 10 hours. After completion of the reaction, the reaction solution was added to water, extracted with ethyl acetate (50 ml × 2), and the layers were separated. The organic phase was washed with water, saturated brine, and dried with anhydrous sodium sulfate. Concentration under reduced pressure gave 4-dimethylaminoethoxycinnamic acid methyl ester as a white solid (yield: 93.6%, purity: 99.8%).
References:
CN110305024,2019,A Location in patent:Paragraph 0029-0052
