methyl 8-amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylate synthesis
- Product Name:methyl 8-amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylate
- CAS Number:248919-96-2
- Molecular formula:C11H13N3O2
- Molecular Weight:219.24
Yield:248919-96-2 6.53 g (75%)
Reaction Conditions:
in cyclohexanone
Steps:
1.2 Synthesis of Methyl 8-amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylate
Example 1.2 Synthesis of Methyl 8-amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylate To a suspension of 5,6-diamino-nicotinic acid methyl ester (1 eq., 5.1 g) in cyclohexanone (50 ml) bromobutanone (1.2 equiv., 3.9 ml) was added over 10 min. The mixture was heated to 100° C. (inner temperature) and stirred 2.5 h at this temperature. The mixture was cooled to room temperature and the pale solid was filtered off and was washed with TBME (3*10 ml). Drying under reduced pressure at 45° C. Yield: 6.53 g (75%).
References:
Elman, Bjorn;Erbeck, Silke;Thiemermann, Eric US2004/39013, 2004, A1
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