3-(DIMETHYLAMINO)-1-(2-METHYL-1H-IMIDAZOL-5-YL)-2-PROPEN-1-ONE synthesis
1synthesis methods
- Product Name:3-(DIMETHYLAMINO)-1-(2-METHYL-1H-IMIDAZOL-5-YL)-2-PROPEN-1-ONE
- CAS Number:251096-49-8
- Molecular formula:C9H13N3O
- Molecular Weight:179.22
Yield:403792-70-1 29%
Reaction Conditions:
at 100; for 56 h;
Steps:
1
5-(3-Dimethylaminoprop-2-enoyl)-2-methylimidazole (350 mg, 1.95 mmol) was suspended in DMFDMA (14 ml) and the mixture stirred and heated at 100° C. for 56 hours. The excess DMFDMA was removed by evaporation and the residue purified by chromatography eluting with DCM/MeOH (94:6) to give the title compound 111 mg, (29%) as a solid. NMR (CDCl3): 2.40 (s, 3H), 3.00 (s, 6H), 3.88 (s, 3H), 5.50 (d, 1H), 7.47 (s, 1H), 7.65 (d, 1H); m/z: 194.
References:
US2004/14776,2004,A1 Location in patent:Page/Page column 31