4-(2-（dimethylamino）ethoxy)benzene-1-sulfonylchloride synthesis
- Product Name:4-(2-（dimethylamino）ethoxy)benzene-1-sulfonylchloride
- CAS Number:259183-86-3
- Molecular formula:C10H14ClNO3S
- Molecular Weight:263.74
13468-02-5
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Yield:-
Reaction Conditions:
with chlorosulfonic acid in dichloromethane;
Steps:
I.2 Preparation of [2-(dimethylamino)ethoxy]phenyl-4-sulfonyl chloride
Intermediate Example 2 Preparation of [2-(dimethylamino)ethoxy]phenyl-4-sulfonyl chloride 2 g of N,N-dimethyl-N-[(2-phenoxy)ethyl]amine was dissolved in 10 ml of dichloromethane and 3 ml of chlorosulfonic acid was slowly added under ice cooling. The mixture was stirred at room temperature for 3 hr and poured into ice. Dichloromethane (100 ml) was added and aqueous layer was neutralized by concentrated sodium carbonate solution with keeping temperature under 4° C. Dichloromethane layer was dried over anhydrous magnesium sulfate and evaporated under reduced pressure. 0.8 g of [2-(dimethylamino)ethoxy]phenyl-4-sulfonyl chloride was obtained.
References:
US6559167,2003,B1
108-95-2
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