Ethyl 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate synthesis
- Product Name:Ethyl 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate
- CAS Number:261767-10-6
- Molecular formula:C11H12O4
- Molecular Weight:208.21
3943-73-5
66 suppliers
$16.00/100mg
1643-19-2
981 suppliers
$12.00/10g
107-06-2
405 suppliers
$14.00/25g
261767-10-6
35 suppliers
$39.00/100mg
Yield:261767-10-6 94%
Reaction Conditions:
with hydrogenchloride;sodium chloride;potassium carbonate in water;
Steps:
1 2,3-Dihydrobenzo[1,4]dioxin-5-carboxylic acid ethyl ester
A mixture of ethyl 2,3-dihydroxybenzoate (1000 g), tetra-n-butyl-ammonium bromide (880 g), potassium carbonate (1552 g), 1,2-dichloroethane (3216 g), and water (10 kg) was refluxed for 5 hours. The solution was cooled and extracted with toluene. The extract was washed with a solution of 1N hydrochloric acid and sodium chloride. The solution was partially concentrated and filtered through silica gel (300 g). The filtrated was concentrated to give the title compound (1074 g, 94%); m.p. 48-51° C.
References:
US6172062,2001,B2
4442-53-9
174 suppliers
$7.00/1g
64-17-5
706 suppliers
$10.00/50g
261767-10-6
35 suppliers
$39.00/100mg