4-Thiazolecarboxylic acid, 2-(2,4-difluorophenyl)-, hydrazide synthesis

1synthesis methods

Product Name:4-Thiazolecarboxylic acid, 2-(2,4-difluorophenyl)-, hydrazide
CAS Number:262589-16-2
Molecular formula:C10H7F2N3OS
Molecular Weight:255.24

ETHYL 2-(2,4-DIFLUOROPHENYL)THIAZOLE-4-CARBOXYLATE

175276-93-4
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4-Thiazolecarboxylic acid, 2-(2,4-difluorophenyl)-, hydrazide

262589-16-2
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Yield:262589-16-2 72%

Reaction Conditions:

with hydrazine hydrate in ethanol at 20; for 14 h;Inert atmosphere;

References:

Hoveyda, Hamid R.;Fraser, Graeme L.;Roy, Marie-Odile;Dutheuil, Guillaume;Batt, Frédéric;El Bousmaqui, Mohamed;Korac, Julien;Lenoir, Fran?ois;Lapin, Alexey;No?l, Sophie;Blanc, Sébastien [Journal of Medicinal Chemistry,2015,vol. 58,# 7,p. 3060 - 3082]