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ChemicalBook CAS DataBase List (3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester
263769-22-8

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester synthesis

4synthesis methods
214335-16-7 Synthesis
(3S,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylicacidmethylester

214335-16-7
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(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

263769-22-8
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Yield:263769-22-8 100%

Reaction Conditions:

with sodium methylate in methanol;Heating;epimerization;

References:

Tamiz, Amir P.;Smith, Miles P.;Enyedy, Istvan;Flippen-Anderson, Judith;Zhang, Mei;Johnson, Kenneth M.;Kozikowski, Alan P. [Bioorganic and Medicinal Chemistry Letters,2000,vol. 10,# 15,p. 1681 - 1686]

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