Ethanone, 1-[2-(dimethylamino)-5-pyrimidinyl]- (9CI) synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: PdCl₂(PPh₃)2 / dimethylformamide / 2 h / 90 °C
2: 58 percent / HCl / acetone / 20 °C

References:

Matulenko, Mark A.;Lee, Chih-Hung;Jiang, Meiqun;Frey, Robin R.;Cowart, Marlon D.;Bayburt, Erol K.;DiDomenico Jr., Stanley;Gfesser, Gregory A.;Gomtsyan, Arthur;Guo, Zhu Zheng;McKie, Jeffery A.;Stewart, Andrew O.;Yu, Haixia;Kohlhaas, Kathy L.;Alexander, Karen M.;McGaraughty, Steve;Wismer, Carol T.;Mikusa, Joseph;Marsh, Kennan C.;Snyder, Ronald D.;Diehl, Marilyn S.;Kowaluk, Elizabeth A.;Jarvis, Michael F.;Bhagwat, Shripad S. [Bioorganic and Medicinal Chemistry,2005,vol. 13,# 11,p. 3705 - 3720]