4-Chloro-7-fluoroquinoline-3-carboxylic acid ethyl ester synthesis

5synthesis methods

Product Name:4-Chloro-7-fluoroquinoline-3-carboxylic acid ethyl ester
CAS Number:26893-13-0
Molecular formula:C12H9ClFNO2
Molecular Weight:253.66

26892-97-7 Synthesis

7-FLUORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

26892-97-7
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4-Chloro-7-fluoroquinoline-3-carboxylic acid ethyl ester

26893-13-0
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Yield:26893-13-0 89%

Reaction Conditions:

with trichlorophosphate at 100; for 0.333333 h;

Steps:

A mixture of 7-fluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester (2.45 g,10.0 mmol; see step (b) above) and POCl₃ (3 mL) was stirred at 100 ⁰C for 20 min, cooled and concentrated. The residue was washed with heptane (3x30 mL) and dried. Yield 2.26 g (89 %) as an off-white solid.¹H-NMR (CDCl₃₅ 400 MHz) δ 9.52 (IH₅ s), 8.73 (IH₅ dd), 8.32 (IH₅ dd), 7.82 (IH, ddd), 4.57 (2H₅ q), 1.51 (3H₅ 1).

References:

WO2007/51982,2007,A1 Location in patent:Page/Page column 44

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References

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References