ChemicalBook CAS DataBase List 2-[[(3aR,4S,6R,6aS)-6-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-acetic acid methyl ester

2-[[(3aR,4S,6R,6aS)-6-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-acetic acid methyl ester synthesis

8synthesis methods

Product Name:2-[[(3aR,4S,6R,6aS)-6-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-acetic acid methyl ester
CAS Number:274693-25-3
Molecular formula:C27H32F2N6O5S
Molecular Weight:590.64

145783-14-8 Synthesis

4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE

145783-14-8
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2-[[(3aR,4S,6R,6aS)-6-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-acetic acid methyl ester

274693-25-3
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Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: iron; acetic acid / 4 h
2.1: triethylamine / tetrahydrofuran / 24 h / Reflux
3.1: acetic acid; sodium nitrite / 1 h / 20 °C
4.1: potassium carbonate / 2 h
5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / -10 °C
5.2: 16 h / -10 °C
6.1: methanol / 60 °C

References:

EP2586773,2013,A1

145783-15-9 Synthesis