ChemicalBook CAS DataBase List (2R,3R,5S)-3,5-DiMethyl-1-benzyloxy-2-hydroxy-8-(4-Methoxyphenoxy)-4-octanone

(2R,3R,5S)-3,5-DiMethyl-1-benzyloxy-2-hydroxy-8-(4-Methoxyphenoxy)-4-octanone synthesis

3synthesis methods

Product Name:(2R,3R,5S)-3,5-DiMethyl-1-benzyloxy-2-hydroxy-8-(4-Methoxyphenoxy)-4-octanone
CAS Number:276690-15-4
Molecular formula:C24H32O5
Molecular Weight:400.51

60656-87-3 Synthesis

60656-87-3
175 suppliers
$17.00/1g

(4S)-7-(4-Methoxyphenoxy)-4-Methyl-3-heptanone

276690-14-3
11 suppliers
$275.00/2.5mg

(2R,3R,5S)-3,5-DiMethyl-1-benzyloxy-2-hydroxy-8-(4-Methoxyphenoxy)-4-octanone

276690-15-4
8 suppliers
$650.00/1mg

Yield:276690-15-4 64%

Reaction Conditions:

Stage #1: (S)-(+)-7-(4'-Methoxyphenoxy)-4-methylheptan-3-onewith titanium tetrachloride;N-ethyl-N,N-diisopropylamine in dichloromethane at -78; for 1.5 h;Metallation;
Stage #2: benzyloxyacetoaldehyde in dichloromethane at -78; for 2 h;Aldol reaction;

References:

Enders, Dieter;Geibel, Gunter;Osborne, Simon [Chemistry - A European Journal,2000,vol. 6,# 8,p. 1302 - 1309]

20744-03-0
17 suppliers
$130.00/1g

276690-15-4
8 suppliers
$650.00/1mg

References

118943-23-0
19 suppliers
$115.00/1g

276690-15-4
8 suppliers
$650.00/1mg

References