ChemicalBook CAS DataBase List 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one synthesis

1synthesis methods

Product Name:2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
CAS Number:277299-70-4
Molecular formula:C12H14N2O
Molecular Weight:202.25

141-97-9 Synthesis

141-97-9
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3,4-Dimethylphenylhydrazine hydrochloride

13636-53-8
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2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

277299-70-4
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$20.00/1g

Yield:277299-70-4 64%

Reaction Conditions:

in acetic acid

Steps:

1.a a
a 1-(3,4-Dimethylphenyl)-3-methyl-3-pyrazolin-5-one A solution of 3,4-dimethylphenylhydrazine (7.3 g; 0.053 mol.) and ethyl acetoacetate (6.9 g; 0.053 mol.) in glacial acetic acid (50.0 mL) was stirred and heated at 100° for 24h. The solvent was evaporated and the product purified by chromatography (silica gel, 50% ethyl acetate/hexanes) to afford the title compound (16.8 g; 64%). MS(ES) m/z 203 [M+H].

References:

SmithKline Beecham Corporation US6552008, 2003, B1

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