2-Methyl-5-(piperidin-4-yl)-1,3,4-oxadiazole hydrochloride synthesis

1synthesis methods

Product Name:2-Methyl-5-(piperidin-4-yl)-1,3,4-oxadiazole hydrochloride
CAS Number:280110-76-1
Molecular formula:C8H14ClN3O
Molecular Weight:203.6693

280110-69-2 Synthesis

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

280110-69-2
42 suppliers
$26.00/250mg

2-Methyl-5-(piperidin-4-yl)-1,3,4-oxadiazole hydrochloride

280110-76-1
24 suppliers
$244.00/250mg

Yield:280110-76-1 66%

Reaction Conditions:

with hydrogenchloride in ethyl acetate at -20 - 20;Inert atmosphere;

References:

Jansen, Michaela;Rabe, Holger;Strehle, Axelle;Dieler, Sandra;Debus, Fabian;Dannhardt, Gerd;Akabas, Myles H.;Lüddens, Hartmut [Journal of Medicinal Chemistry,2008,vol. 51,# 15,p. 4430 - 4448] Location in patent:experimental part