![](/CAS/GIF/28485-18-9.gif)
2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-SULFONYL CHLORIDE synthesis
- Product Name:2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-SULFONYL CHLORIDE
- CAS Number:28485-18-9
- Molecular formula:C4H3ClN2O4S
- Molecular Weight:210.6
![Uracil](/CAS/GIF/66-22-8.gif)
66-22-8
773 suppliers
$5.00/10g
![2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-SULFONYL CHLORIDE](/CAS/GIF/28485-18-9.gif)
28485-18-9
34 suppliers
$47.03/250mg
Yield:28485-18-9 92.3%
Reaction Conditions:
with chlorosulfonic acid;thionyl chloride at 25 - 75; for 12.5 h;
Steps:
4.1.1. The synthesis of 2,4-dihydroxypyrimidine-5-sulfonyl chloride(1)
2, 4-dihydroxypyrimidine (6 g, 53.57 mmol) and thionylchloride(SOCl2) (10 mL, 89.22 mmol) were added to a 100 mL reaction askat 25C. After chlorosulfonic acid (HSO3Cl) (16 g, 138.05 mmol) wasadded at room temperature for 1.5 h. The reaction was stirred at60C for 4 h in an oil bath and then at 75C for 7 h. The reactionmixture was added to a mixture of ice and glacial acetic acid (1:1).The precipitate was precipitated and suction ltered, washedrepeatedly and dried at 50C to give compound 1 as white powder.Yield: 92.30%.
References:
Li, Xin-yang;Liang, Jing-wei;Mohamed O, Kamara;Zhang, Ting-jian;Lu, Guo-Qing;Meng, Fan-hao [European Journal of Medicinal Chemistry,2018,vol. 154,p. 267 - 279]