ChemicalBook CAS DataBase List Furo[3,4-c]pyridin-3(1H)-one, 4-chloro-1,1-dimethyl-

Furo[3,4-c]pyridin-3(1H)-one, 4-chloro-1,1-dimethyl- synthesis

5synthesis methods

Product Name:Furo[3,4-c]pyridin-3(1H)-one, 4-chloro-1,1-dimethyl-
CAS Number:285991-71-1
Molecular formula:C9H8ClNO2
Molecular Weight:197.62

145887-88-3 Synthesis

145887-88-3
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Furo[3,4-c]pyridin-3(1H)-one, 4-chloro-1,1-dimethyl-

285991-71-1
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Yield:285991-71-1 76.3%

Reaction Conditions:

with phosphorus pentachloride at 130 - 150;

Steps:

4-Chloro-1,1-dimethylfuro[3,4-c]pyridine-3(1H)-one V.

A mixture of 1 (IV series) and phosphorus pentacloride in molar ratio 1:1.1 was heated with reflux condenser at 130-150°C for15-20 min. After cooling, crashed ice was added. Precipitated crystals were filtered, washed with water and acetone and recrystallized from ethanol. Yield 76.3 %

References:

Hovhannisyan, Anna;Pham, The Hien;Bouvier, Dominique;Piroyan, Alexander;Dufau, Laure;Qin, Lixian;Cheng, Yan;Melikyan, Gagik;Reboud-Ravaux, Michèle;Bouvier-Durand, Michelle [Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,# 6,p. 1571 - 1580] Location in patent:supporting information