N2,N2-DIMETHYL-3-(TRIFLUOROMETHYL)PYRIDINE-2,5-DIAMINE synthesis

3synthesis methods

Product Name:N2,N2-DIMETHYL-3-(TRIFLUOROMETHYL)PYRIDINE-2,5-DIAMINE
CAS Number:288247-16-5
Molecular formula:C8H10F3N3
Molecular Weight:205.18

Dimethyl-(5-nitro-3-trifluoromethyl-pyridin-2-yl)-amine

813425-49-9
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N2,N2-DIMETHYL-3-(TRIFLUOROMETHYL)PYRIDINE-2,5-DIAMINE

288247-16-5
8 suppliers
$320.00/250mg

Yield:288247-16-5 34%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; for 1 h;

Steps:

104.3 Step 3:

N,N-dimethyl-5-nitro-3-(trifluoromethyl)pyridin-2-amine (200 mg, 0.85 mmol) was dissolved in methanol. 10 % Pd / C (40 mg) was added to it. The resulting mixture was stirred at room temperature under hydrogen atmosphere for 1 h. The mixture was filtered through celite bed and the filtrate was concentrated under reduced pressure to afford the N2,N2-dimethyl-3-(trifluoromethyl)pyridine-2,5-diamine (60 mg, 34 %).

References:

WO2013/13817,2013,A1 Location in patent:Page/Page column 131

25391-60-0 Synthesis

25391-60-0
49 suppliers
$27.00/100mg

288247-16-5
8 suppliers
$320.00/250mg

References

99368-67-9 Synthesis

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

99368-67-9
130 suppliers
$7.00/250mg

288247-16-5
8 suppliers
$320.00/250mg

References