ChemicalBook CAS DataBase List 4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide

4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide synthesis

3synthesis methods

Product Name:4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide
CAS Number:2908-71-6
Molecular formula:C6H9Br2N3
Molecular Weight:0

4-Amino-5-methoxymethyl-2-methylpyrimidine

769-82-4
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4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide

2908-71-6
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Yield:2908-71-6 87%

Reaction Conditions:

with hydrogen bromide in acetic acid at 100;Temperature;Solvent;

Steps:

3.4 A method for synthesizing 4-amino-2-methyl-5-(bromomethyl)pyrimidine hydrobromide, Include the following steps:

S4. Add 100 grams of ring-closing product to a 1-liter jar.Slowly add 500 ml of 33% HBr/HOAc solution.Slowly warm the system to 100°C,Maintain this temperature for 8-16 hours,TLC determines the endpoint of the reaction.After the reaction is completed, 20 grams of acidic activated carbon is added while hot, and the mixture is stirred for 30 minutes and then filtered. The filtrate is concentrated under pressure and dried to dryness. 30 milliliters of anhydrous ethanol is added, and the crystals are cooled and filtered.149 g of the target product was dried to give a yield of 87%.

References:

CN107382877,2017,A Location in patent:Paragraph 0031; 0032-0086; 0091; 0096; 0101

5-ethoxymethyl-2-methylpyrimidin-4-ylamine

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2908-71-6
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References

Pyrimidine, 4-chloro-5-(ethoxymethyl)-2-methyl-

749835-80-1
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2908-71-6
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References