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51485-76-8

(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: POCl3 / 1,2-dichloro-ethane / -5 °C
2: 62 percent / piperidine / pyridine / 1.) 100 deg C, 12 h, 2.) reflux

References:

New, James S.;Christopher, William L.;Yevich, Joseph P.;Butler, Rhett;Schlemmer, R. Francis;et al. [Journal of Medicinal Chemistry,1989,vol. 32,# 6,p. 1147 - 1156]