ChemicalBook CAS DataBase List (2E)-3-(2,5-Dimethoxyphenyl)-2-propenoic acid

(2E)-3-(2,5-Dimethoxyphenyl)-2-propenoic acid synthesis

5synthesis methods

Product Name:(2E)-3-(2,5-Dimethoxyphenyl)-2-propenoic acid
CAS Number:38489-74-6
Molecular formula:C11H12O4
Molecular Weight:208.21

141-82-2 Synthesis

141-82-2
749 suppliers
$5.00/25g

93-02-7 Synthesis

93-02-7
566 suppliers
$6.00/5g

(2E)-3-(2,5-Dimethoxyphenyl)-2-propenoic acid

38489-74-6
17 suppliers
$95.00/500mg

Yield:38489-74-6 99%

Reaction Conditions:

Stage #1: 2,5-dimethoxybenzaldehydewith pyridine at 20; for 0.166667 h;Inert atmosphere;
Stage #2: malonic acidwith piperidine for 5 h;Reflux;Inert atmosphere;

References:

Bal, Mathias;Bomon, Jeroen;Liao, Yuhe;Maes, Bert U. W.;Sels, Bert F.;Sergeyev, Sergey;Van Den Broeck, Elias;Van Speybroeck, Veronique [Angewandte Chemie - International Edition,2020,vol. 59,# 8,p. 3063 - 3068][Angew. Chem.,2020,vol. 132,p. 3087 - 3092,6] Location in patent:supporting information