(2E)-4-(2,4-difluorophenyl)-4-oxobut-2-enoic acid synthesis
2synthesis methods
- Product Name:(2E)-4-(2,4-difluorophenyl)-4-oxobut-2-enoic acid
- CAS Number:1354707-64-4
- Molecular formula:C10H6F2O3
- Molecular Weight:212.15
Yield:1354707-64-4 60%
Reaction Conditions:
Stage #1: Glyoxilic acidwith acetic anhydride;ytterbium(III) triflate at 20; for 0.166667 h;
Stage #2: 2',4'-difluoroacetophenonewith acetic acid in acetic acid at 140; for 0.5 h;Microwave irradiation;Sealed tube;
References:
Tolstoluzhsky, Nikita;Nikolaienko, Pavlo;Gorobets, Nikolay;Van Der Eycken, Erik V.;Kolos, Nadezhda [European Journal of Organic Chemistry,2013,# 24,p. 5364 - 5369] Location in patent:supporting information
