(2E,4E)-2,4-Octadienal synthesis

Yield:30361-28-5 81%

Reaction Conditions:

with oxygen;palladium diacetate;trifluoroacetic acid in dimethyl sulfoxide at 80;Sealed tube;

Steps:

4 Example 4
In a 100 mL round bottom flask, add the raw material Id, palladium acetate (10 mol%) to seal the round bottom flask and evacuate it, and fill the round bottom flask with oxygen. Next, add the treated DMSO and trifluoroacetic acid in sequence. After all the materials are added, stir thoroughly in an oxygen atmosphere. The reaction mixture was stirred at 80 ° C until TLC (thin-layer chromatography) monitoring. The reaction was no longer in progress. After the reaction was completed, the mixture was cooled to room temperature, and the mixture was dispersed with 100 mL of ethyl acetate. The organic phase was extracted three times with 5 mL of water, and the organic phase was extracted three times with 5 mL of saturated saline. Sodium is dried for more than 30 min. Filtration, concentration and column chromatography gave the target compound IId.The (2E, 4E) -octa-2,4-dienal (IId) product was a white liquid with a yield of 81%.

References:

Northwest University;Wang Yongqiang;Pan Gaofei CN110483265, 2019, A Location in patent:Paragraph 0019; 0020

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