ChemicalBook CAS DataBase List 2H-1-Benzopyran-2-one, 8-chloro-

2H-1-Benzopyran-2-one, 8-chloro- synthesis

8synthesis methods

Product Name:2H-1-Benzopyran-2-one, 8-chloro-
CAS Number:33491-29-1
Molecular formula:C9H5ClO2
Molecular Weight:180.59

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Yield:33491-29-1 88%

Reaction Conditions:

at 175; for 6 h;Acidic conditions;

Steps:

Step 1: 8-chloro-2H-chromen-2-one

A mixture of 3-chloro-2-hydroxybenzaldehyde (1 g, 6.4 mmol) and CH3COOH (1.3 g, 12.8mmol) in Ac₂0 (45 mL) was heated to 175 °C for 6 hrs. The mixture was then cooled down to rt. The precipitate which formed was collected to give 8-chloro-2H-chromen-2-one (1.02 g, 88%) as a brown solid. ESI-MS (EI⁺, m/z): 181.0 [M+l]⁺.

References:

WO2014/152213,2014,A2 Location in patent:Page/Page column 48

95-57-8 Synthesis