2H-Indol-2-one,1,3-dihydro-5-(1-methylethyl)-(9CI) synthesis

4synthesis methods

Product Name:2H-Indol-2-one,1,3-dihydro-5-(1-methylethyl)-(9CI)
CAS Number:156232-25-6
Molecular formula:C11H13NO
Molecular Weight:175.23

1,3-dihydro-5-(1-Methylethenyl)-2H-Indol-2-one

1168722-73-3
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2H-Indol-2-one,1,3-dihydro-5-(1-methylethyl)-(9CI)

156232-25-6
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Yield:156232-25-6 99%

Reaction Conditions:

with hydrogen;palladium on activated charcoal in methanol; under 760.051 Torr; for 3 h;

Steps:

A127.A

5-isopropenylindolin-2-one (15 mg, 0.0866 mmol) was then dissolved into MeOH and the solution purged with N_{2 (g)}. 2 mg of 10 % Pd/C (Degussa type) was then added and the mixture purged briefly with H_{2 (g)}. The mixture was stirred under 1 atm of H_{2 (g}>for 3 hours and then filtered through a pad of celite. The solvent was removed to give 15 mg, 99 % of the product as an off-white solid. MS ESI 176.0 [M + H]⁺, calcd for [C₁₁H₁₃NO + H]⁺ 176.11

References:

WO2009/79767,2009,A1 Location in patent:Page/Page column 189

150560-58-0
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References

99-88-7
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$8.00/5g

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References

Acetamide, 2-(hydroxyimino)-N-[4-(1-methylethyl)phenyl]-

68701-52-0
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References