2H-Indol-2-one, 4-chloro-1,3-dihydro-3-hydroxy- synthesis

Yield:-

Reaction Conditions:

with diethylamine in acetone at 50; for 14 h;

Steps:

3

(E)-4-chloro-3-(2-oxopropylidene)indolin-2-one ( 10)[0141] To a solution of 4-chloro isatin (500 mg, 2.75 mmol) in acetone (5 mL) was added diethylamine (314 μ, 3.02 mmol) at room temperature. The mixture was heated to 50 °C for 14 hours with magnetic stirring and then concentrated under reduced pressure.

References:

WO2012/78519,2012,A2 Location in patent:Page/Page column 48