ChemicalBook CAS DataBase List (2S)-1,4-Dioxan-2-yl-methanol

(2S)-1,4-Dioxan-2-yl-methanol synthesis

9synthesis methods

Product Name:(2S)-1,4-Dioxan-2-yl-methanol
CAS Number:406913-93-7
Molecular formula:C5H10O3
Molecular Weight:118.13

1,4-Dioxane, 2-[(phenylmethoxy)methyl]-, (2S)-

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Yield:406913-93-7 89%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in ethanol; for 18 h;

Steps:

84 (2S)-1,4-dioxan-2-ylmethanol

To a so[ution of Intermediate 83 (1 .25 g, 4.74 mmo[) in ethano[ (20 mL) was added pa[[adium, 10 % on carbon (192 mg) and the reaction mixture stirred under an atmosphere of hydrogen for 18 h. The reaction mixture was fi[tered through a p[ugof Ce[ite, washing with EtOAc, and concentrated under reduced pressure toafford 630 mg (89% yie[d) of the tit[e compound as pa[e ye[[ow oi[.1H NMR (500 MHz, Ch[oroform-d): 6 [ppm] 3.85 - 3.67 (m, 5H), 3.66 - 3.57 (m, 2H),3.55 (dd, J = 11.7, 5.9 Hz, 1H), 3.46 (dd, J = 11.1, 10.0 Hz, 1H), 1.75 (5, 1H).

References:

WO2016/91776,2016,A1 Location in patent:Page/Page column 233