(2S)-4-methyl-2-(1H-tetrazol-1-yl)pentanoic acid synthesis

Yield:1218436-73-7 84%

Reaction Conditions:

with sodium azide in ethanol at 80;

Steps:

3.3. General procedure for the synthesis of tetrazoles

General procedure: Amino acid (10 mmole), sodium azide (0.65 g, 10 mmole) and Cu nano catalyst (20 mg) were added to a solution of TEOF (4.4 g,5 ml, 30 mmole) in ethanol (5 ml). The solution was stirred and the mixture heated at 80 °C for 1-7 h depends on the substrate and completion of the reaction which monitored with TLC. Then,H2O (20 ml) was added, the Cu catalyst filtered, the filtrate concentrated and the solvent removed in vacuo. The obtained tetrazoles recrystallized in ethanol and characterized by comparing its physical and spectroscopic data with those reported in the literature(Scheme 1).

References:

Ariannezhad, Maryam;Habibi, Davood;Heydari, Somayyeh [Polyhedron,2019,vol. 160,p. 170 - 179]