3-[1,1'-biphenyl]-4-yl-3-oxopropanenitrile synthesis
13synthesis methods
- Product Name:3-[1,1'-biphenyl]-4-yl-3-oxopropanenitrile
- CAS Number:78443-35-3
- Molecular formula:C15H11NO
- Molecular Weight:221.26
![N-METHOXY-N-METHYL-[1,1'-BIPHENYL]-4-CARBOXAMIDE](/CAS/20180703/GIF/101335-77-7.gif)
Yield:78443-35-3 91%
Reaction Conditions:
Stage #1: acetonitrilewith methyllithium;lithium bromide in tetrahydrofuran;diethyl ether at -78; for 0.5 h;Inert atmosphere;
Stage #2: N-methoxy-N-methyl-[1,1'-biphenyl]-4-carboxamide in tetrahydrofuran;diethyl ether at -78; for 1.5 h;Inert atmosphere;
References:
Mamuye, Ashenafi Damtew;Castoldi, Laura;Azzena, Ugo;Holzer, Wolfgang;Pace, Vittorio [Organic and Biomolecular Chemistry,2015,vol. 13,# 7,p. 1969 - 1973] Location in patent:supporting information