3-[1,3,4]Oxadiazol-2-yl-benzoic acid synthesis
1synthesis methods
- Product Name:3-[1,3,4]Oxadiazol-2-yl-benzoic acid
- CAS Number:1176505-26-2
- Molecular formula:C9H6N2O3
- Molecular Weight:190.16
Yield:1176505-26-2 51%
Reaction Conditions:
with toluene-4-sulfonic acid at 60; for 4 h;
Steps:
21.2
Step 2 Synthesis of 3-[1,3,4]Oxadiazol-2-yl-benzoic acid p-Toluene sulfonic acid (15.8 mg, 0.083 mmol) was added to a solution of 3-hydrazinocarbonyl-benzoic acid (150 mg, 0.83 mmol) in triethylorthoformate (2.37 g, 7.5 mL, 16.6 mmol) and stirring was continued with heating at 60° C. for 4 hrs. The reaction mixture was diluted with water and the resulting precipitate was isolated to afford 80 mg (51%) of 3-[1,3,4]oxadiazol-2-yl-benzoic acid.
References:
US2010/160323,2010,A1 Location in patent:Page/Page column 25