ChemicalBook CAS DataBase List 3-(1,3-BENZOTHIAZOL-2-YL)PHENOL

3-(1,3-BENZOTHIAZOL-2-YL)PHENOL synthesis

13synthesis methods

Product Name:3-(1,3-BENZOTHIAZOL-2-YL)PHENOL
CAS Number:25389-28-0
Molecular formula:C13H9NOS
Molecular Weight:227.28

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Yield:25389-28-0 99%

Reaction Conditions:

with yttrium(III) chloride in ethanol; for 0.5 h;Reflux;Green chemistry;

Steps:

A general procedure for preparation of dihydropyrazines 3

General procedure: YCl₃(0.0098 g, 0.05 mmol) were dissolved in 10mL EtOH and stirred until the soliddissolved completely in refluxing, then 2-aminobenzenethiols 1a (0.118 mL, 1.1mmol) and benzaldehyde 2a (0.101 ml, 1.0 mmol) was added into thereaction mixture. After 30min, TLC showed the reaction to be complete. Thereaction mixture was cooled to r.t., and then evaporated in vacuum. The productpurified by column chromatography (PE-EtOAc= 20:1) to give white solid 3a(0.2092 g, 99%)

References:

Fan, Li-Yan;Shang, Ying-Hui;Li, Xiang-Xiong;Hua, Wen-Jun [Chinese Chemical Letters,2015,vol. 26,# 1,p. 77 - 80] Location in patent:supporting information

95-16-9 Synthesis