3-(1,3-BENZOTHIAZOL-2-YL)PROPANOIC ACID synthesis

7synthesis methods

Product Name:3-(1,3-BENZOTHIAZOL-2-YL)PROPANOIC ACID
CAS Number:29198-86-5
Molecular formula:C10H9NO2S
Molecular Weight:207.25

108-30-5 Synthesis

108-30-5
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137-07-5
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29198-86-5
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$57.50/250mg

Yield:29198-86-5 660 mg

Reaction Conditions:

in benzene; for 2 h;Reflux;

Steps:

11 Synthesis of 3-(1,3-benzothiazol-2-yl)propanoic acid (lntermediate-36):

Synthesis of 3-(1,3-benzothiazol-2-yl)propanoic acid (lntermediate-36): Starting material-7 (3.97mmol) in benzene was added drop wise to the solution of Starting Material-6 (3.97mmol) in benzene. The resulting solution was heated to reflux for 2 hours. After 2 hours the reaction mass was cooled to room temperature and was extracted with 10% sodium hydroxide solution. The aqueous layer was acidified using Conc.HCI (3ml) at 0°C. The resulting solids were filtered and dried at room temperature to get lntermediate-36 (660mg).

References:

WO2013/111150,2013,A1 Location in patent:Page/Page column 90