3-(1,3-thiazol-2-ylcarbamoyl)propanoic acid synthesis
- Product Name:3-(1,3-thiazol-2-ylcarbamoyl)propanoic acid
- CAS Number:19692-00-3
- Molecular formula:C7H8N2O3S
- Molecular Weight:200.21
Yield:-
Reaction Conditions:
in tetrahydrofuran; for 2 h;Reflux;
Steps:
1 Preparation of Compound 1a
In 100 ml round bottom flask, add 2 - amino thiazole (10mmol) and succinic anhydride (12mmol), 15 ml tetrahydrofuran (solvent A) stirring and dissolving, heating reflux 2 hours to carry out the acylation reaction, reducing the temperature of the precipitate solid, filtering to obtain solid, ethanol to recrystallize the purification. Recrystallization the specific method is: to the 1g treats heavily in initial crystallized product, dropwise adding ethanol to 3 ml, heating to reflux, until the initial products all dissolved, continue to reflux 10min, then slowly cooling to separate out the solid, filtered to get the pure product.
References:
CN106831637,2017,A Location in patent:Paragraph 0060-0063
329205-47-2
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