3'',1''']quaterphenyl synthesis
- Product Name:3'',1''']quaterphenyl
- CAS Number:106785-63-1
- Molecular formula:C24H17Br
- Molecular Weight:385.3
Yield:106785-63-1 89%
Reaction Conditions:
with bis-triphenylphosphine-palladium(II) chloride;potassium phosphate in ethanol;water;toluene at 55 - 65; for 3 h;Inert atmosphere;
Steps:
1 (Synthesis of Intermediate 4)
3-Terphenylboronic acid (10.1 g, 37.0 mmol),Toluene (100 mL) obtained by nitrogen bubbling of 1-bromo-4-iodobenzene (10.5 g, 37.0 mmol),Ethanol (46 mL),An aqueous solution of tripotassium phosphate (2.0 mol / L, 46 mL) was added in order, and the mixture was heated to 55 ° C.Then, PdCl2 (PPh3) 2 (0.26 g, 0.37 mmol) was added, and the mixture was stirred at 65 ° C. for 3 hours.After cooling to room temperature, a saturated aqueous sodium chloride solution was added, and extraction was performed using toluene.The organic layer was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate, and the solvent was distilled off under reduced pressure.The residue was subjected to silica gel column chromatography to obtain Intermediate 4 (yield 12.7 g, yield 89%).
References:
JP2021/147325,2021,A Location in patent:Paragraph 0366; 0375-0377
18620-02-5
17 suppliers
inquiry
106785-63-1
9 suppliers
inquiry
