3-(2,4,5-Trifluorophenyl)propanoic acid synthesis
- Product Name:3-(2,4,5-Trifluorophenyl)propanoic acid
- CAS Number:651047-33-5
- Molecular formula:C9H7F3O2
- Molecular Weight:204.15
247170-17-8
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651047-33-5
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Yield:651047-33-5 95%
Reaction Conditions:
Stage #1: 3-(2,4,5-trifluoro-phenyl)-acrylic acidwith acetic acidactive carbon; for 0.333333 h;
Stage #2: with hydrogen;palladium 10% on activated carbon in acetic acid;
Steps:
49.1 EXAMPLE 49; 1-[3-(2,4,5-trifluorophenyl)propyl]-3-(1-piperazinyl)-2(1H)-pyrazinone, Trifluoroacetate; Step 1. 3-(2,4,5-trifluorophenyl)propionic acid.
3-(2,4,5-Trifluorophenyl) acrylic acid (3.50 g, 17.3 mmol) was dissolved in glacial acetic acid (40 mL) and treated with active carbon (-0.5 g). The mixture was stirred for 20 min, the carbon filtered off and washed with glacial acetic acid (20 mL). To the resulting solution Pd on carbon catalyst (0.45 g, 10% Pd) was added and the mixture was stirred under hydrogen at atmospheric pressure overnight. The suspension was filtered and concentrated in vacuo. Residual acetic acid was removed by addition of a small volume of toluene followed by concentration in vacuo. The resulting oil crystallized upon standing and this material was dried in vacuum at 50 C to give 3.34 g (95%) of the title compound.
References:
WO2004/9586,2004,A1 Location in patent:Page 48
165047-24-5
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651047-33-5
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