3-(2,5-DIMETHYL-PHENOXY)-PROPIONIC ACID synthesis
- Product Name:3-(2,5-DIMETHYL-PHENOXY)-PROPIONIC ACID
- CAS Number:4673-48-7
- Molecular formula:C11H14O3
- Molecular Weight:194.23
Yield:-
Reaction Conditions:
with sodium hydroxide in water;
Steps:
General procedure for the synthesis of aryloxy acetic/propionicacids (2a-q and 3a-q)
General procedure: Equimolar quantities of 2-chloro acetic acid/3-chloro propionicacid (0.05 mol) and appropriate phenol (1a-q) (0.05 mol) were taken in a conical flask, to which aqueous solution of NaOH(0.12 mol in 25 mL water) was slowly added with constant stirring.The solution was stirred for 2 h until the solution turned clear,brown or yellow and then the reaction mixture was evaporatedin a evaporating dish until the solid sodium salt was precipitated. The salt was isolated, dried, dissolved in water and acidified byadding con. HCl. The precipitated aryloxy acetic/propionic acidwas filtered and recrystallized from water or ethanol
References:
Joshi, Shrinivas D.;More, Uttam A.;Koli, Deepshikha;Kulkarni, Manoj S.;Nadagouda, Mallikarjuna N.;Aminabhavi, Tejraj M. [Bioorganic Chemistry,2015,vol. 59,p. 151 - 167]
91132-29-5
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