3-(2-aminophenoxy)benzonitrile synthesis
- Product Name:3-(2-aminophenoxy)benzonitrile
- CAS Number:330942-69-3
- Molecular formula:C13H10N2O
- Molecular Weight:210.23
330942-68-2
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Yield:330942-69-3 99%
Reaction Conditions:
with tin(II) chloride dihdyrate in ethanol; for 4 h;Reflux;
Steps:
586.2 3-(2-(4-[(2-aminosulfonyl)phenyl]benzoylamino)phenoxy)benzamidine
Step 2:
A solution of 3-(2-nitrophenoxy)benzonitrile (1.21 g, 5 mmol, 1.0 equiv) in 30 mL of EtOH was treated with SnCl2.2H2O (3.38 g, 3 equiv) at reflux for 4 h.
The volatile was evaporated and the residue was redissolved in EtOAc, washed with saturated aqueous NaHCO3 and 1N NaOH.
The organic layer was dried over MgSO4, filtered and evaporated to give 3-(2-aminophenoxy)benzonitrile (1.04 g, 99%). MS found for C13H11N2O (M+H)+: 211.
References:
US9108922,2015,B2 Location in patent:Page/Page column 435
873-62-1
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