3-(2-BROMOPHENYL)-1,1,1-TRIFLUORO-2-PROPANONE synthesis
- Product Name:3-(2-BROMOPHENYL)-1,1,1-TRIFLUORO-2-PROPANONE
- CAS Number:898787-57-0
- Molecular formula:C9H6BrF3O
- Molecular Weight:267.04
383-63-1
475 suppliers
$10.00/25g
18698-97-0
333 suppliers
$10.00/1g
898787-57-0
15 suppliers
$340.00/1g
Yield:898787-57-0 74%
Reaction Conditions:
Stage #1: ortho-bromophenylacetic acidwith n-butyllithium;diisopropylamine in tetrahydrofuran;hexane at -65 - 20; for 2 h;Inert atmosphere;
Stage #2: ethyl trifluoroacetate, at -65 - 20; for 1 h;
References:
Cao, Jing;Cheng, Aolin;Liu, Tao;Song, Guanshui;Zhang, Kun;Zhang, Liangliang;Zhao, Baoguo;Zhao, Guoqing;Zhou, Qinghai [Angewandte Chemie - International Edition,2021,vol. 60,# 37,p. 20166 - 20172][Angew. Chem.,2021,vol. 133,# 37,p. 20328 - 20334] Location in patent:supporting information