3-(2-chlorophenyl)-1,2,4-oxadiazol-5-ol synthesis

5synthesis methods

Product Name:3-(2-chlorophenyl)-1,2,4-oxadiazol-5-ol
CAS Number:16672-15-4
Molecular formula:C8H5ClN2O2
Molecular Weight:196.59

56935-60-5 Synthesis

56935-60-5
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541-41-3
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16672-15-4
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Yield:16672-15-4 76%

Reaction Conditions:

Stage #1: 2-chloro-benzamide oxime;chloroformic acid ethyl esterwith triethylamine in dichloromethane at 0 - 20;
Stage #2: with sodium hydroxide in dimethyl sulfoxide at 20; for 3 h;

References:

Soldatova, Natalia S.;Semenov, Artem V.;Geyl, Kirill K.;Baykov, Sergey V.;Shetnev, Anton A.;Konstantinova, Anna S.;Korsakov, Mikhail M.;Yusubov, Mekhman S.;Postnikov, Pavel S. [Advanced Synthesis and Catalysis,2021,vol. 363,# 14,p. 3566 - 3576] Location in patent:supporting information

2039-87-4 Synthesis